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KMID : 0617320020110010236
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Journal of Pharmacetical Sceiences Ewha Womans University
2002 Volume.11 No. 1 p.236 ~ p.240
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Colon Delivery of Prednisolone Based on Chitosan Coated Polysaccharide Tablets
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Park, Hyun-Sun
Lee, Jue-Yeon/Cho, Sun-Hye/Baek, Hyon-Jin/Lee, Seung-Jin
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Abstract
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Colon drug delivery is advantageous in the treatment of colonic disease and oral delivery ofdrugs unstable or suceptible to enzymatic degradation in upper Gl tract. In this study, multi-layer coated system that is resistant to gastric and small intestinal conditions but can be easilydegraded by colonic bacterial enzymes was designed to achieve effective colon delivery ofprednisolone. Variousiy coated tablets containing prednisolone were fabricated using chitosanand cellulose acetate phthalate (CAP) as coating materiais. Release aspects of prednisolonein simulated gastrointestinal fluid and rat colonic extracts (CERM) were investigated. Aiso,colonic bacterial degradation study of chitosan was peformed in CERM. From these results, athree layer (CAP/ChitosarCAP) coated system exhibited gastric and small intestinal resis-tance to the release of prednisolone in vitro most eHectively. The rapid increase of predniso-ione in CERM was revealed as due to the degradation of the chitosan membrane by bacterialenzymes. The designed system could be used potentially used as a carrier for colon deliveryof prednisolone by regulating drug release in stomach and the small intestine.
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